Dynamics of microbiota during mechanical ventilation in aspiration pneumonia.

ABSTRACT:

Background

The emergence of multi-drug resistant pathogens is an urgent health-related problem, and the appropriate use of antibiotics is imperative. It is often difficult to identify the causative bacteria in patients with aspiration pneumonia because tracheal aspirate contains contaminants of oral bacteria. We investigated the dynamics of microbiota in mechanically ventilated patients with aspiration pneumonia to develop a treatment strategy.

Methods

Twenty-two intubated patients with aspiration pneumonia were recruited. Saliva and tracheal aspirate of the subjects were collected at three time points: (A) within 2 h after intubation, (B) just before administration of antibiotics, and (C) 48-72 h after administration of antibiotics. The microbiota in each specimen was analy

SUBMITTER: Otsuji K 

PROVIDER: S-EPMC6929358 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature