Early-life exposure to humidifier disinfectant determines the prognosis of lung function in children.

ABSTRACT:

Background

Use of humidifier disinfectants (HD) at home leads to chemical airborne exposure, causing HD associated lung injury (HDLI) with high mortality. However, the lung function in children diagnosed with HDLI is not well studied. We investigated the effect of HD exposure on lung function, prognosis, and exposure characteristics associated with the lung function phenotype in children.

Methods

Eighty-one children diagnosed with HDLI in a nationwide cohort were tested for spirometry and diffusing capacity of the lung for carbon monoxide (DLco) from July 2013 and followed up with at five time points over 2 years. The results were compared with 122 children without HD exposure as controls. Home investigation and questionnaire analysis were conducted to assess HD inhalation e

SUBMITTER: Cho HJ 

PROVIDER: S-EPMC6929365 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature