BIN1 rs744373 variant shows different association with Alzheimer's disease in Caucasian and Asian populations.

ABSTRACT:

Background

The association between BIN1 rs744373 variant and Alzheimer's disease (AD) had been identified by genome-wide association studies (GWASs) as well as candidate gene studies in Caucasian populations. But in East Asian populations, both positive and negative results had been identified by association studies. Considering the smaller sample sizes of the studies in East Asian, we believe that the results did not have enough statistical power.

Results

We conducted a meta-analysis with 71,168 samples (22,395 AD cases and 48,773 controls, from 37 studies of 19 articles). Based on the additive model, we observed significant genetic heterogeneities in pooled populations as well as Caucasians and East Asians. We identified a significant association between rs744373 polymorph

SUBMITTER: Han Z 

PROVIDER: S-EPMC6929404 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature