ScReClassify: post hoc cell type classification of single-cell rNA-seq data.

ABSTRACT:

Background

Single-cell RNA-sequencing (scRNA-seq) is a fast emerging technology allowing global transcriptome profiling on the single cell level. Cell type identification from scRNA-seq data is a critical task in a variety of research such as developmental biology, cell reprogramming, and cancers. Typically, cell type identification relies on human inspection using a combination of prior biological knowledge (e.g. marker genes and morphology) and computational techniques (e.g. PCA and clustering). Due to the incompleteness of our current knowledge and the subjectivity involved in this process, a small amount of cells may be subject to mislabelling.

Results

Here, we propose a semi-supervised learning framework, named scReClassify, for 'post hoc' cell type identification from

SUBMITTER: Kim T 

PROVIDER: S-EPMC6929456 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature