Wtest: an integrated R package for genetic epistasis testing.

ABSTRACT:

Background

With the increasing amount of high-throughput genomic sequencing data, there is a growing demand for a robust and flexible tool to perform interaction analysis. The identification of SNP-SNP, SNP-CpG, and higher order interactions helps explain the genetic etiology of human diseases, yet genome-wide analysis for interactions has been very challenging, due to the computational burden and a lack of statistical power in most datasets.

Results

The wtest R package performs association testing for main effects, pairwise and high order interactions in genome-wide association study data, and cis-regulation of SNP and CpG sites in genome-wide and epigenome-wide data. The software includes a number of post-test diagnostic and analysis functions and offers an integrated tool

SUBMITTER: Sun R 

PROVIDER: S-EPMC6929460 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature