Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study.

ABSTRACT:

Background

The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single-center study. The impact of hydroxocobalamin on the risk of acute kidney injury (AKI) and survival after smoke inhalation in a multicenter setting remains unexplored.

Methods

We conducted a multicenter retrospective study in 21 intensive care units (ICUs) in France. We included patients admitted to an ICU for smoke inhalation between January 2011 and December 2017. We excluded patients discharged at home alive within 24 h of admission. We assessed the risk of AKI (primary endpoint), severe AKI, major adverse kidney (MAKE) events, and survival (secondary endp

SUBMITTER: Depret F 

PROVIDER: S-EPMC6929494 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature