Polygenic risk scores for Alzheimer's disease, and academic achievement, cognitive and behavioural measures in children from the general population.

ABSTRACT:

Objective

Several studies report a polygenic component of risk for Alzheimer's disease. Understanding whether this polygenic signal is associated with educational, cognitive and behavioural outcomes in children could provide an earlier window for intervention.

Methods

We examined whether polygenic risk scores (PRS) at varying P-value thresholds in children from the Avon Longitudinal Study of Parents and Children were associated with academic achievement, cognitive and behavioural measures in childhood and adolescence.

Results

We did not detect any evidence that the genome-wide significant PRS (5x10-8) were associated with these outcomes. PRS at the highest P-value threshold examined (P ≤ 5x10-1) were associated with lower academic achievement in adolescents (Key Stage

SUBMITTER: Korologou-Linden R 

PROVIDER: S-EPMC6929531 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature