Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence.

ABSTRACT:

Background

Individuals with cocaine addiction are characterized by under-responsiveness to natural reinforcers. As part of the dopaminergic pathways, the hypothalamus supports motivated behaviors. Rodent studies suggested inter-related roles of the hypothalamus in regulating drug and food intake. However, few studies have investigated hypothalamic responses to drugs and food or related cues in humans.

Methods

We examined regional responses in 20 cocaine-dependent and 24 healthy control participants exposed to cocaine/food (cocaine dependent) and food (healthy control) vs neutral cues during functional magnetic resonance imaging. We examined the relationship between imaging findings and clinical variables and performed mediation analyses to examine the inter-relationships bet

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6929672 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature