The etiology of DSM-5 alcohol use disorder: Evidence of shared and non-shared additive genetic effects.

ABSTRACT:

Background

Alcoholism is a multifactorial disorder influenced by multiple gene loci, each with small effect. Studies suggest shared genetic influences across DSM-IV alcohol dependence symptoms, but shared effects across DSM-5 alcohol use disorder remains unknown. We aimed to test the assumption of genetic homogeneity across the 11 criteria of DSM-5 alcohol use disorder (AUD).

Methods

Data from 2596 alcohol using individuals of European ancestry from the Study of Addiction: Genetics and Environment were used to examine the genomewide SNP-heritability (h2SNP) and SNP-covariance (rGSNP) between 11 DSM-5 AUD symptoms. Phenotypic relationships between symptoms were examined to confirm an underlying liability of AUD and the SNP-heritability of the observed latent trait and the co-

SUBMITTER: Palmer RHC 

PROVIDER: S-EPMC6929687 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature