Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy.

ABSTRACT: The hypoxia of the tumor microenvironment (TME) often hinders the effectiveness of cancer treatments, especially O₂-dependent photodynamic therapy (PDT). Methods: An integrated iridium oxide (IrO₂)-manganese dioxide (MnO₂) nanotheranostic agent was fabricated through bovine serum albumin (BSA)-based biomineralization of Ir³⁺ and Mn²⁺. BSA was first covalently modified with chlorin e6 (Ce6), and used to fabricate multifunctional BSA-Ce6@IrO₂/MnO₂ nanoparticles (NPs) for computed X-ray tomography (CT) and photoacoustic (PA) imaging-guided PDT and photothermal (PTT) therapy of cancer. Extensive in vitro and in vivo studies were performed. Results: The theranostic agent produced can relieve

SUBMITTER: Wu J 

PROVIDER: S-EPMC6929990 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature