Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials.

ABSTRACT: Pharmacological interventions of diabetic gastroparesis (DG) constitute an essential element of a patient's management. This article aimed to systematically review the available pharmacological approaches of DG, including their efficacy and safety. A total of 24 randomised clinical trials (RCTs) that investigated the efficacy and/or safety of medications targeting DG symptoms were identified using several online databases. Their results revealed that metoclopramide was the only approved drug for accelerating gastric emptying and improving disease symptoms. However, this medication may have several adverse effects on the cardiovascular and nervous systems, which might be resolved with a new intranasal preparation. Acceptable alternatives are oral domperidone for patients without cardiovascu

SUBMITTER: Asha MZ 

PROVIDER: S-EPMC6930032 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature