Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis.

ABSTRACT: The link between gut microbiome and brain is being slowly acknowledged due to the speculated role of resident gut microbial community in altering the functions of gut-brain axis (GBA). Recently, a number of microbial metabolites (referred to as neuro-active metabolites) produced through tryptophan metabolism have been suggested to influence the GBA. In view of this, the current study focuses on microbial tryptophan metabolism pathways which produce neuro-active metabolites. An in silico analysis was performed on bacterial genomes as well as publicly available gut microbiome data. The results provide a comprehensive catalog of the analyzed pathways across bacteria. The analysis indicates an enrichment of tryptophan metabolism pathways in five gut-associated phyla, namely, Actinobacte

SUBMITTER: Kaur H 

PROVIDER: S-EPMC6930238 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature