Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice.

ABSTRACT: Reduced activity of the prefrontal cortex (PFC) is seen in mood disorders including depression and anxiety. The mechanisms of this hypofrontality remain unclear. Because of their specific physiological properties, parvalbumin-expressing (PV⁺) inhibitory interneurons contribute to the overall activity of the PFC. Our recent work using a chronic stress mouse model showed that stress-induced increases in prefrontal PV expression correlates with increased anxiety-like behaviors in female mice. Our goal is now to provide a causal relationship between changes in prefrontal PV⁺ cells and changes in emotional behaviors in mice. We first show that, in addition to increasing overall level of PV expression, chronic stress increases the activity of prefrontal PV⁺ cells

SUBMITTER: Page CE 

PROVIDER: S-EPMC6930291 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature