Progressive brain atrophy in Parkinson's disease patients who convert to mild cognitive impairment.

ABSTRACT:

Aims

Cognitive impairment is a common symptom in the trajectory of Parkinson's disease (PD). However, the pathological underpinning is not fully known. We aimed to explore the critical structural alterations in the process of cognitive decline and its relationships with the dopaminergic deficit and the level of related cerebrospinal fluid (CSF) proteins.

Methods

Ninety-four patients with PD and 32 controls were included in this study. Neuropsychological tests were performed at baseline and after 28 months to identify which patients had normal cognition and which ones developed PD-MCI after follow-up ("converters"). Gray matter atrophy was assessed in cross-sectional and longitudinal analyses, respectively. The associations between altered GMV with dopamine transporter (DAT)

SUBMITTER: Zhou C 

PROVIDER: S-EPMC6930819 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature