Effects of Antirejection Drugs on Innate Immune Cells After Kidney Transplantation.

ABSTRACT: Over the last decades, our understanding of adaptive immune responses to solid organ transplantation increased considerably and allowed development of immunosuppressive drugs targeting key alloreactive T cells mechanism. As a result, rates of acute rejection dropped and short-term graft survival improved significantly. However, long-term outcomes are still disappointing. Recently, increasing evidence supports that innate immune responses plays roles in allograft rejection and represents a valuable target to further improve long-term allograft survival. Innate immune cells are activated by molecules with stereotypical motifs produced during injury (i.e., damage-associated molecular patterns, DAMPS) or infection (i.e., pathogen-associated molecular patterns, PAMPs). Activated innate immune c

SUBMITTER: Zaza G 

PROVIDER: S-EPMC6930910 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature