Functional variant of IL33 is associated with survival of osteosarcoma patients.

ABSTRACT:

Objectives

Previous genome-wide association study showed that GLDC/IL33 loci were associated with overall survival in patients with osteosarcoma (OS). We performed a replication study to explore whether variants of GLDC/IL33 are associated with the survival of OS patients and to further verify their functional role in the gene expression.

Methods

A total of 216 patients with OS were enrolled. The overall survival time was calculated from the date of diagnosis till the date of last follow-up or mortality. Two SNPs were genotyped, including rs55933544 and rs74438701. OS specimens were obtained from 72 patients during surgery. The gene expression level of IL33 and GLDC was evaluated by qPCR. Patients were classified into two groups according to the 5

SUBMITTER: Lin Q 

PROVIDER: S-EPMC6931128 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature