Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies.

ABSTRACT:

Purpose

To determine the accuracy of a handheld ultrasound-guided optoacoustic tomography (US-OT) probe developed for human deep-tissue imaging in ex vivo assessment of tumor margins postlumpectomy.

Methods

A custom-built two-dimensional (2D) US-OT-handheld probe was used to scan 15 lumpectomy breast specimens. Optoacoustic signals acquired at multiple wavelengths between 700 and 1100 nm were reconstructed using model linear algorithm, followed by spectral unmixing for lipid and deoxyhemoglobin (Hb). Distribution maps of lipid and Hb on the anterior, posterior, superior, inferior, medial, and lateral margins of the specimens were inspected for margin involvement, and results were correlated with histopathologic findings. The agreement in tumor margin assessment between US-OT

SUBMITTER: Goh Y 

PROVIDER: S-EPMC6931190 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature