Brain imaging correlates of self- and other-reflection in schizophrenia.

ABSTRACT:

Background

An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results.

Methods

Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing.

Results

Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial pre

SUBMITTER: Fuentes-Claramonte P 

PROVIDER: S-EPMC6931228 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature