One-year changes in brain microstructure differentiate preclinical Huntington's disease stages.

ABSTRACT:

Objective

To determine whether brain imaging markers of tissue microstructure can detect the effect of disease progression across the preclinical stages of Huntington's disease.

Methods

Longitudinal microstructural changes in diffusion imaging metrics (mean diffusivity and fractional anisotropy) were investigated in participants with presymptomatic Huntington's disease (N = 35) stratified into three preclinical subgroups according to their estimated time until onset of symptoms, compared with age- and gender-matched healthy controls (N = 19) over a 1y period.

Results

Significant differences were found over the four groups in change of mean diffusivity in the posterior basal ganglia and the splenium of the corpus callosum. This overall effect was driven by significant

SUBMITTER: Pflanz CP 

PROVIDER: S-EPMC6931230 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature