Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.

ABSTRACT:

Background

Minority groups of African descent experience disproportionately greater asthma morbidity compared with other racial groups, suggesting that genetic variation from a common ancestry could influence exacerbation risk.

Objective

We evaluated clinical trial measures in the context of self-reported race and genetic ancestry to identify risk factors for asthma exacerbations.

Methods

One thousand eight hundred forty multiethnic subjects from 12 Asthma Clinical Research Network and AsthmaNet trials were analyzed for incident asthma exacerbations with Poisson regression models that included clinical measures, self-reported race (black, non-Hispanic white, and other), and estimates of global genetic African ancestry in a subgroup (n = 760).

Results

Twenty-fou

SUBMITTER: Grossman NL 

PROVIDER: S-EPMC6931257 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature