Age-Related Differences in Brain Morphology and the Modifiers in Middle-Aged and Older Adults.

ABSTRACT: Brain structural morphology differs with age. This study examined age-differences in surface-based morphometric measures of cortical thickness, volume, and surface area in a well-defined sample of 8137 generally healthy UK Biobank participants aged 45-79 years. We illustrate that the complexity of age-related brain morphological differences may be related to the laminar organization and regional evolutionary history of the cortex, and age of about 60 is a break point for increasing negative associations between age and brain morphology in Alzheimer's disease (AD)-prone areas. We also report novel relationships of age-related cortical differences with individual factors of sex, cognitive functions of fluid intelligence, reaction time and prospective memory, cigarette smoking, alcohol consum

SUBMITTER: Zhao L 

PROVIDER: S-EPMC6931275 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature