Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans.

ABSTRACT: Although the molecular effects of many anaesthetics have been well characterized, a network-level explanation for how these changes lead to loss of consciousness remains unclear. Studies using electroencephalography have characterized changes in neural oscillations in the cortex at specific frequency bands during propofol-induced anaesthesia and modelling work suggests these changes result from changes in thalamocortical functional connectivity. However, it is unclear if the neurophysiological changes seen at the cortex are due to enhanced or disrupted thalamocortical communication. Direct recordings from these sites during anaesthesia that could be used to confirm such models are rare. We recorded local field potentials from the ventral intermediate nucleus of the thalamus and electrocort

SUBMITTER: Malekmohammadi M 

PROVIDER: S-EPMC6931391 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature