Role of spatial dispersion of repolarization in reentry around a functional core versus reentry around a fixed anatomical core.

ABSTRACT:

Introduction

Successful initiation of spiral wave reentry in the neonatal rat ventricular myocyte (NRVM) monolayer implicitly assumes the presence of spatial dispersion of repolarization (DR), which is difficult to quantify. We recently introduced a NRVM monolayer that utilizes anthopleurin-A to impart a prolonged plateau to the NRVM action potential. This was associated with a significant degree of spatial DR that lends itself to accurate quantification.

Methods and results

We utilized the monolayer and fluorescence optical mapping of intracellular calcium transients (F_Cai ) to systematically study and compare the contribution of spatial dispersion of the duration of F_Cai (as a surrogate of DR) to induction of spiral wave reentry around a functional co

SUBMITTER: Himel HD 

PROVIDER: S-EPMC6931426 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature