Sequence of cardiovascular autonomic alterations after fingolimod initiation.

ABSTRACT: Homeostasis between heart rate and blood pressure is based on several interacting regulatory reflexes, which become influenced by fingolimod initiation. The aim of this study was to determine the sequence of changes in cardiovascular autonomic regulation after fingolimod initiation. Twenty-seven patients with relapsing-remitting multiple sclerosis underwent continuous electrocardiogram recording during the first 6 hr after the first dose of fingolimod. In addition to the time interval between two consecutive R-peaks (RR interval), blood pressure and heart rate variability (HRV) were measured on hourly basis. Cardiac parasympathetic and sympathetic regulation were assessed by the different components of HRV. HRV demonstrated an enhancement in cardiac parasympathetic regulation starting 1 hr

SUBMITTER: Simula S 

PROVIDER: S-EPMC6931564 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature