Combining noninvasive risk stratification parameters improves the prediction of mortality and appropriate ICD shocks.

ABSTRACT:

Background

Sudden cardiac death (SCD) results from a complex interplay of abnormalities in autonomic function, myocardial substrate and vulnerability. We studied whether a combination of noninvasive risk stratification tests reflecting these key players could improve risk stratification.

Methods

Patients implanted with an ICD in whom 24-hr holter recordings were available prior to implant were included. QRS fragmentation (fQRS) was selected as measure of myocardial substrate and a high ventricular premature beat count (VPB >10/hr) for arrhythmic vulnerability. From receiver operating characteristics analysis, detrended fluctuation analysis (DFA), turbulence slope, and deceleration capacity were selected for autonomic function. Adjusted Cox regression analysis with comparison

SUBMITTER: Vandenberk B 

PROVIDER: S-EPMC6931642 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature