Ontology highlight
ABSTRACT:
SUBMITTER: Adane B
PROVIDER: S-EPMC6931909 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cell reports 20190401 1
The NADPH-dependent oxidase NOX2 is an important effector of immune cell function, and its activity has been linked to oncogenic signaling. Here, we describe a role for NOX2 in leukemia-initiating stem cell populations (LSCs). In a murine model of leukemia, suppression of NOX2 impaired core metabolism, attenuated disease development, and depleted functionally defined LSCs. Transcriptional analysis of purified LSCs revealed that deficiency of NOX2 collapses the self-renewal program and activates ...[more]