Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors.

ABSTRACT: Bacteria convert changes in sensory inputs into alterations in gene expression, behavior, and lifestyles. A common lifestyle choice that bacteria make is whether to exhibit individual behavior and exist in the free-living planktonic state or to engage in collective behavior and form sessile communities called biofilms. Transitions between individual and collective behaviors are controlled by the chemical cell-to-cell communication process called quorum sensing. Here, we show that quorum sensing represses Pseudomonas aeruginosa biofilm formation and virulence by activating expression of genes encoding the KinB-AlgB two-component system (TCS). Phospho-AlgB represses biofilm and virulence genes, while KinB dephosphorylates and thereby inactivates AlgB. We discover that the photoreceptor BphP

SUBMITTER: Mukherjee S 

PROVIDER: S-EPMC6932827 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature