Conditional disease-free survival in high-risk renal cell carcinoma treated with sunitinib.

ABSTRACT: BACKGROUND:Disease-free survival (DFS) did not reflect accurate individual prognosis after initial diagnosis. As conditional DFS (CDFS) could provide dynamic prognostic information, we evaluated CDFS in these patients treated with or without sunitinib. RESULTS:A total of 1329 patients with median follow-up 6.54 years were enrolled. CDFS improved continuously with disease-free survivorship increasing in both sunitinib and placebo group with minimal difference. In placebo arm, the CDFS of surviving to five year after living 1, 2, 3, and 4 years were 65%, 78%, 87%, and 95% (observed 5-year DFS: 51%). Dynamic changes of HR showed adjuvant sunitinib decrease relapse risks during the first 1.5 years after surgery (P < 0.03). CONCLUSIONS:Our study provided contemporary data of CDFS and change of

SUBMITTER: Shao N 

PROVIDER: S-EPMC6932878 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature