CiRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653.

ABSTRACT:

Background

Circular RNAs have been widely explored as potential biomarkers and therapeutic targets in bladder cancer; however, few have been functionally characterized.

Results

ciRs-6 is expressed at low levels in cancer tissues and advanced tumor grades and stages, and its expression correlates with better outcomes for bladder cancer patients. In vitro and in vivo, ciRs-6 was shown to suppress bladder cancer growth by sponging miR-653 to elevate March1 levels. March1 is an E3 ubiquitin ligase that has been proven to suppress bladder cancer growth; knocking down March1 in ciRs-6 overexpressed bladder cancer cells reversed the tumor suppressive effect of ciRs-6.

Conclusions

Our study identifies an oncogenic role of ciRs-6 and suggests its usefulness as a novel biomarke

SUBMITTER: Su Y 

PROVIDER: S-EPMC6932879 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature