Glycolysis gene expression profilings screen for prognostic risk signature of hepatocellular carcinoma.

ABSTRACT: Metabolic changes are the markers of cancer and have attracted wide attention in recent years. One of the main metabolic features of tumor cells is the high level of glycolysis, even if there is oxygen. The transformation and preference of metabolic pathways is usually regulated by specific gene expression. The aim of this study is to develop a glycolysis-related risk signature as a biomarker via four common cancer types. Only hepatocellular carcinoma was shown the strong relationship with glycolysis. The mRNA sequencing and chip data of hepatocellular carcinoma, breast invasive carcinoma, renal clear cell carcinoma, colorectal adenocarcinoma were included in the study. Gene set enrichment analysis was performed, profiling three glycolysis-related gene sets, it revealed genes associated wi

SUBMITTER: Jiang L 

PROVIDER: S-EPMC6932884 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature