Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach.

ABSTRACT: Despite a growing number of studies on longevity in Drosophila, genetic factors influencing lifespan are still poorly understood. In this paper we propose a conceptually new approach for the identification of novel longevity-associated genes and potential target genes for SNPs in non-coding regions by utilizing the knowledge of co-location of various loci, governed by the three-dimensional architecture of the Drosophila genome. Firstly, we created networks between genes/genomic regions harboring SNPs deemed to be significant in two longevity GWAS summary statistics datasets using intra- and inter-chromosomal interaction frequencies (Hi-C data) as a measure of co-location. These networks were further extended to include regions strongly interacting with previously selected reg

SUBMITTER: Hall BS 

PROVIDER: S-EPMC6932890 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature