Circ5912 suppresses cancer progression via inducing MET in bladder cancer.

ABSTRACT:

Background

Increasing evidence suggests that circular RNAs play a key role in regulating bladder cancer progression. However, this remains to be fully elucidated.

Results

In this study, we reanalyzed our previous RNA sequence, and circ5912 was found to downregulate significantly in bladder cancer tissues compared with normal control. Expression of circ5912 inversely correlates with bladder cancer grade, stage, metastasis, and better patient outcomes. In vitro and in vivo, circ5912 has been shown to repress transforming growth factor β signaling, which suppresses proliferation, invasion and migration of bladder cancer induced by mesenchymal-to epithelial transition.

Conclusions

Our study firstly demonstrate that circ5912 regulates mesenchymal-to epithelia

SUBMITTER: Su Y 

PROVIDER: S-EPMC6932894 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature