Reactive oxygen species metabolism-based prediction model and drug for patients with recurrent glioblastoma.

ABSTRACT: BACKGROUND:Tumor recurrence is the main cause of poor prognosis of GBM. Finding the characteristics of recurrent GBM that provide early warning of tumor recurrence can provide guidance for the clinical treatment of recurrent GBM. RESULTS:Reactive oxygen species (ROS) biosynthetic processes was significantly elevated in recurrent GBM. The recurrent risk score based on the ROS biosynthetic process was closely related to tumor purity and tumor immune functions. The quantitative risk assessment system could be used to predict the recurrence time of GBM. Gallic acid, a compound with high anti-oxidation activity and low cytotoxicity, was screened as a potential chemotherapy sensitizer for recurrent GBM. CONCLUSION:The quantitative risk assessment system based on ROS biosynthetic process could be

SUBMITTER: Tan N 

PROVIDER: S-EPMC6932921 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature