Cannabichromene is a cannabinoid CB₂ receptor agonist.

ABSTRACT:

Background and purpose

Cannabichromene (CBC) is one of the most abundant phytocannabinoids in Cannabis spp. It has modest antinociceptive and anti-inflammatory effects and potentiates some effects of Δ⁹ -tetrahydrocannabinol in vivo. How CBC exerts these effects is poorly defined and there is little information about its efficacy at cannabinoid receptors. We sought to determine the functional activity of CBC at cannabinoid CB₁ and CB₂ receptors.

Experimental approach

AtT20 cells stably expressing haemagglutinin-tagged human CB₁ and CB₂ receptors were used. Assays of cellular membrane potential and loss of cell surface receptors were performed.

Key results

CBC activated CB₂ but not CB₁ recepto

SUBMITTER: Udoh M 

PROVIDER: S-EPMC6932936 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature