Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.

ABSTRACT:

Background and purpose

Acute pancreatitis (AP) is a common acute abdominal condition, frequently associated with intestinal barrier dysfunction, which aggravates AP retroactively. Butyrate exhibits anti-inflammatory effects in a variety of inflammatory diseases. However, its potential beneficial effect on AP and the underlying mechanisms have not been investigated.

Experimental approach

Experimental AP was induced by caerulein hyperstimulation in wild-type and GPR109A^-/- mice. Sodium butyrate was administered intragastrically for 7 days prior to caerulein hyperstimulation. Anti-inflammatory mechanisms of butyrate were further investigated in peritoneal macrophages.

Key results

Butyrate prophylaxis attenuated AP as shown by reduced serum amylase and lipase l

SUBMITTER: Pan X 

PROVIDER: S-EPMC6932943 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature