Prognostic Role of KRAS mRNA Expression in Breast Cancer.

ABSTRACT:

Purpose

We investigated the prognostic role of KRAS mRNA expression in breast cancer using The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) databases.

Methods

Clinical and biological data of 1,093 breast cancers from TCGA database and 1,904 breast cancers from METABRIC database were analyzed. Overall survival (OS) and breast cancer-specific survival (BCSS) were determined.

Results

The group with high KRAS mRNA expression showed worse survival than the group with low KRAS mRNA expression regarding both OS (p = 0.012 in TCGA, p < 0.001 in METABRIC) and BCSS (p = 0.001 in METABRIC). According to multivariate analysis, the level of KRAS mRNA expression was an indepen

SUBMITTER: Hwang KT 

PROVIDER: S-EPMC6933029 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature