Impact of early nausea on varenicline adherence and smoking cessation.

ABSTRACT:

Background and aims

Varenicline effectiveness may be related to the level of adherence, which might be reduced by adverse effects such as nausea. The aim of the study was to test a possible effect of nausea on smoking cessation outcomes mediated by adherence.

Design

Mediation path analysis.

Setting

Multiple sites within Canada and the United States.

Participants

Treatment-seeking smokers receiving varenicline from two smoking cessation clinical trials: Quit2Live (NCT01836276; n = 449) and Pharmacogenetics of Nicotine Addiction Treatment (PNAT) (NCT01314001; n = 421).

Measurements

Nausea severity was collected through self-report and adherence was biologically assessed using varenicline concentrations (Quit2Live, plasma sample at week 4; PNAT, saliva samp

SUBMITTER: Peng AR 

PROVIDER: S-EPMC6933078 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature