C-Reactive Protein Gene Variants in Depressive Symptoms & Antidepressants Efficacy.

ABSTRACT: OBJECTIVE:Although the pathogenesis of depression remains unclear, C-reactive protein (CRP) levels are commonly elevated in depressed patients. Thus, CRP single-nucleotide polymorphisms (SNPs) that influence CRP levels may be associated with depression. In the present study, we explored whether CRP SNPs are related to depressive symptoms and antidepressants efficacy in Han Chinese patients. METHODS:We analyzed data from 440 patients with first-episode depression. We obtained genome CRP SNPs, scores of the 17-item Hamilton Rating Scale for Depression 17 (HAMD17) and its four-factor at baseline and after 6 weeks. Quantitative trait analysis was performed using UNPHASED software and curative effects were analyzed using SPSS software. RESULTS:Male patients with SNP rs1800947G exhibited lower i

SUBMITTER: Li X 

PROVIDER: S-EPMC6933135 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature