Immune reconstitution inflammatory syndrome in HIV infected late presenters starting integrase inhibitor containing antiretroviral therapy.

ABSTRACT:

Background

Integrase inhibitors (INI) induce a rapid decline of HIV-RNA in plasma and CD4⁺ T-cell recovery in blood. Both characteristics are also associated with immune reconstitution inflammatory syndrome (IRIS). Whether the use of INI-containing combination antiretroviral therapy (cART) increases the risk of IRIS is being questioned.

Methods

Study within the Dutch ATHENA HIV observational cohort. HIV-1 infected late presenters initiating cART after March 2009 were included if they had <200 CD4⁺ T-cells per μL and were diagnosed with an opportunistic infection. IRIS was defined either according to the criteria by French et al. (IRIS_FRENCH) or by a clinical IRIS diagnosis of the physician (IRIS_CLINICAL). The primary outcome

SUBMITTER: Wijting IEA 

PROVIDER: S-EPMC6933261 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature