Pathway-Dependent Regulation of Sleep Dynamics in a Network Model of the Sleep-Wake Cycle.

ABSTRACT: Sleep is a fundamental homeostatic process within the animal kingdom. Although various brain areas and cell types are involved in the regulation of the sleep-wake cycle, it is still unclear how different pathways between neural populations contribute to its regulation. Here we address this issue by investigating the behavior of a simplified network model upon synaptic weight manipulations. Our model consists of three neural populations connected by excitatory and inhibitory synapses. Activity in each population is described by a firing-rate model, which determines the state of the network. Namely wakefulness, rapid eye movement (REM) sleep or non-REM (NREM) sleep. By systematically manipulating the synaptic weight of every pathway, we show that even this simplified model exhibits non-trivi

SUBMITTER: Herice C 

PROVIDER: S-EPMC6933528 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature