Influence of Biocorona Formation on the Transformation and Dissolution of Cobalt Nanoparticles under Physiological Conditions.

ABSTRACT: Cobalt (Co) nanoparticles (NPs) are produced in different applications and unintentionally generated at several occupational and traffic settings. Their diffuse dispersion may lead to interactions with humans and aquatic organisms via different exposure routes that include their transformation/dissolution in biological media. This paper has investigated the particle stability and reactivity of Co NPs (dispersed by sonication prior to exposure) interacting with selected individual biomolecules (amino acids, polypeptides, and proteins) in phosphate-buffered saline (PBS). No or minor adsorption of amino acids (glutamine, glutamic acid, lysine, and cysteine) was observed on the Co NPs, independent of the functional group and charge. Instead, phosphate adsorption resulted in the formation of a

SUBMITTER: Mei N 

PROVIDER: S-EPMC6933593 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature