Associations of Pregnancy History with BMI and Weight Gain in 45-54-Year-Old Women.

ABSTRACT:

Background

Midlife women have a higher risk of cardiometabolic disease than younger women, but the lifelong biological/lifestyle factors responsible for this increase are unclear.

Objectives

We investigated whether pregnancy history is a risk factor for midlife overweight/obesity and evaluated potential hormonal mechanisms.

Methods

The Baltimore Midlife Women's Health Study, a prospective cohort, recruited 772 women aged 45-54 y. Women reported pregnancy characteristics via questionnaires, trained staff measured weight/height to calculate midlife BMI, and serum hormones were assessed by ELISA. Logistic regression models assessed associations of pregnancy history with risk of midlife overweight/obesity and BMI gain since age 18. We additionally explored whether associa

SUBMITTER: Pacyga DC 

PROVIDER: S-EPMC6933615 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature