Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) immune infiltrates play a critical role in tumor progression and response to treatment. Besides stromal tumor infiltrating lymphocytes (sTILs) which have recently reached level 1B evidence as a prognostic marker in triple negative BC, a plethora of methods to assess immune infiltration exists, and it is unclear how these compare to each other and if they can be used interchangeably.

Methods

Two experienced pathologists scored sTIL, intra-tumoral TIL (itTIL), and 6 immune cell types (CD3⁺, CD4⁺, CD8⁺, CD20⁺, CD68⁺, FOXP3⁺) in the International Cancer Genomics Consortium breast cancer cohort using hematoxylin and eosin-stained (n = 243) and immunohistochemistry-stained tissue microa

SUBMITTER: Nederlof I 

PROVIDER: S-EPMC6933637 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature