A patient-centered composite endpoint weighting technique for orthopaedic trauma research.

ABSTRACT: BACKGROUND:This study aimed to address the current limitations of the use of composite endpoints in orthopaedic trauma research by quantifying the relative importance of clinical outcomes common to orthopaedic trauma patients and use those values to develop a patient-centered composite endpoint weighting technique. METHODS:A Best-Worst Scaling choice experiment was administered to 396 adult surgically-treated fracture patients. Respondents were presented with ten choice sets, each consisting of three out of ten plausible clinical outcomes. Hierarchical Bayesian modeling was used to determine the utilities associated with the outcomes. RESULTS:Death was the outcome of greatest importance (mean utility = - 8.91), followed by above knee amputation (- 7.66), below knee amputation (- 6.97), sev

SUBMITTER: Udogwu UN 

PROVIDER: S-EPMC6933647 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature