Transcription factor regulatory modules provide the molecular mechanisms for functional redundancy observed among transcription factors in yeast.

ABSTRACT: BACKGROUND:Current technologies for understanding the transcriptional reprogramming in cells include the transcription factor (TF) chromatin immunoprecipitation (ChIP) experiments and the TF knockout experiments. The ChIP experiments show the binding targets of TFs against which the antibody directs while the knockout techniques find the regulatory gene targets of the knocked-out TFs. However, it was shown that these two complementary results contain few common targets. Researchers have used the concept of TF functional redundancy to explain the low overlap between these two techniques. But the detailed molecular mechanisms behind TF functional redundancy remain unknown. Without knowing the possible molecular mechanisms, it is hard for biologists to fully unravel the cause of TF functional

SUBMITTER: Yang TH 

PROVIDER: S-EPMC6933673 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature