Topological structure analysis of chromatin interaction networks.

ABSTRACT: BACKGROUND:Current Hi-C technologies for chromosome conformation capture allow to understand a broad spectrum of functional interactions between genome elements. Although significant progress has been made into analysis of Hi-C data to identify biologically significant features, many questions still remain open, in particular regarding potential biological significance of various topological features that are characteristic for chromatin interaction networks. RESULTS:It has been previously observed that promoter capture Hi-C (PCHi-C) interaction networks tend to separate easily into well-defined connected components that can be related to certain biological functionality, however, such evidence was based on manual analysis and was limited. Here we present a novel method for analysis of chr

SUBMITTER: Viksna J 

PROVIDER: S-EPMC6933681 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature