LINC00511 accelerated the process of gastric cancer by targeting miR-625-5p/NFIX axis.

ABSTRACT:

Background

Gastric cancer (GC) is a common-sighted cancer which is hard to cure over the world. Substantial researches revealed that long non-coding RNAs (lncRNAs) were fundamental regulators in the process of cancers. Nevertheless, the biological function of LINC00511 and how LINC00511 was involved in the regulatory system in GC remained unclear.

Methods

RIP assays and luciferase reporter assays were performed to illustrate combination between LINC00511 and miR-625-5p. Loss-of-function assays were applied for identifying LINC00511 function in GC.

Results

In our study, LINC00511 was discovered significantly high in expression in GC tissues and cell lines. Moreover, LINC00511 showed a strong expression in I/II and III/IV stage. Knockdown of LINC00511 could inhibit the

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6933746 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature