Proteomic Analysis of Placental Mitochondria Following Trophoblast Differentiation.

ABSTRACT: As gestation proceeds the human placenta is in a constant state of renewal and placental debris is released into the maternal circulation where it can trigger adverse physiological and immunological responses. Trophoblast cells of the placenta differentiate from mononuclear cytotrophoblast cells to fuse and form the syncytiotrophoblast, a multinuclear layer that covers the entire surface of the placenta. As part of this process there are significant changes to cellular cytoskeletal organization and organelle morphology. In this study we have examined the molecular changes that occur in mitochondria from these two cellular compartments and identified differential expression of key proteins that underpin changes in mitochondrial morphology, metabolism and function. Mitochondria were isolated

SUBMITTER: Fisher JJ 

PROVIDER: S-EPMC6933824 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature