ConSurf-DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins.

ABSTRACT: Patterns observed by examining the evolutionary relationships among proteins of common origin can reveal the structural and functional importance of specific residue positions. In particular, amino acids that are highly conserved (i.e., their positions evolve at a slower rate than other positions) are particularly likely to be of biological importance, for example, for ligand binding. ConSurf is a bioinformatics tool for accurately estimating the evolutionary rate of each position in a protein family. Here we introduce a new release of ConSurf-DB, a database of precalculated ConSurf evolutionary conservation profiles for proteins of known structure. ConSurf-DB provides high-accuracy estimates of the evolutionary rates of the amino acids in each protein. A reliable estimate of a query prote

SUBMITTER: Ben Chorin A 

PROVIDER: S-EPMC6933843 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature