IDDomainSpotter: Compositional bias reveals domains in long disordered protein regions-Insights from transcription factors.

ABSTRACT: Protein domains constitute regions of distinct structural properties and molecular functions that are retained when removed from the rest of the protein. However, due to the lack of tertiary structure, the identification of domains has been largely neglected for long (>50 residues) intrinsically disordered regions. Here we present a sequence-based approach to assess and visualize domain organization in long intrinsically disordered regions based on compositional sequence biases. An online tool to find putative intrinsically disordered domains (IDDomainSpotter) in any protein sequence or sequence alignment using any particular sequence trait is available at http://www.bio.ku.dk/sbinlab/IDDomainSpotter. Using this tool, we have identified a putative domain enriched in hydrophilic and disorde

SUBMITTER: Millard PS 

PROVIDER: S-EPMC6933863 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature